Molecular and Cellular Perturbations and (MCPX)
Theses defended since 2012
2025
Safaa MAWAS
Defended on 15/10/2025
Subject: Toxicological assessment of exposure to nanoplastics alone or coated with benzo(a)pyrene on a 3D model of human bronchial epithelium
Guiling CUI
Defended on 02/07/2025
Subject: Structural and functional characterization of CREBBP histone acetyltransferase mutants in human lymphoma and study of CREBBP propionyltransferase activity
2024
Tessa ARNAUD
Defended on 27/09/2024
Subject: Study of the regulation of PTP1B by naphthoquinones: impact on EGFR and cellular consequences
Chloé CHIVE
Defended on 25/09/2024
Subject: Effects of exposure to fine particles on the severity of infection by the Influenza virus
2023
Louise LE COADOU
Defended on 14/12/2023
Subject: Histone lysine methyltransferase SETD2: Functional and structural characterisation of the recurrent oncogenic SETD2 mutation S1624C and of the methylation of a non-histone substrate, the tyrosine kinase ACK1.
2022
Christina MICHAIL
Defended on 15/12/2022
Subject: Structural and functional characterisation of oncogenic mutations in the histone methyltransferase SETD2 and the histone acetyltransferase MOZ
Rongxing LIU
Defended on 19/07/2022
Subject: Molecular effects of the anticancer drug cisplatin on the protein tyrosine phosphatase 1B (PTP1B) and structural impact of PTP1B cancer-associated mutations.
2021
Daniel SANCHEZ GUZMAN
Defense on 8/12/2021
Subject: Development of a 3D bronchial epithelium model for nanotoxicology: analysis of the protein corona formation on silver nanoparticles in the secretome.
2020
Wenchao ZHANG
Defense on 15/12/2020
Subject: Secondary leukemia associated with anti-cancer drugs and epigenetic alterations – Role of the histone acetyltransferase CREBBP.
2019
Qing NIAN
Defense on 16/07/2019
Subject : Inhibition of protein tyrosine phosphatase PTPN2 by etoposide quinone and functional characterization of a pathological mutant.
Jérémy BERTHELET
Defense on 14/06/2019
Subject: Effects of reactive benzene metabolites and an oncogenic mutation on SetD2, a histone methyltransferase.
2018
Chloé PUISNEY
Defense on 27/09/2018
Subject : Fate and impacts of manufactured nanoparticles and from brake wear on the respiratory epithelial barrier.
2016
Romain DUVAL
Defense on 28/04/2016
Subject: Benzene and leukaemia: study of the effect of reactive benzene metabolites on the histone acetyltransferase CBP.
Cécile MATHIEU
Defense on 30/09/2016
Subject : Structure and regulation of brain glycogen phosphorylase.
2015
Mathilde DELAVAL
Defense on 30/11/2015
Subject : Effects of cerium oxide nanoparticles on respiratory epithelium in vitro.
2014
Mélanie LOVERA-LEROUX
Defense on 31/03/2014
Subject : Study of the mechanisms regulating apoptotic cell death by atmospheric particles and their metallic compounds.
Isabelle GEORGE
Defense on 23/09/2014
Subject : Respiratory epithelium, target of inhaled nanoparticles: translocation and long-term effects.
Ximing XU
Defense on 25/09/2014
Subject : Arylamines N-acetyltransferases: cofactor binding, catalytic mechanism and inhibition by dithiocarbamates.
2013
Sandra VRANIC
Defense on 18/02/2013
Subject: Study of the toxicity of nanoparticles on respiratory cells: role of physicochemical properties and endocytosis.
Angélique COCAIGN
Defense on 25/09/2013
Subject : Molecular basis of the detoxification properties of cosmopolitan fungi.
2012
Xavier KUBIAK
Defense on 20/09/2012
Subject : Functional and structural study of atypical arylamine N-acetyltransferases in Legionella pneumophila and Bacillus cereus.
Rina GUADAGNINI
Subject: Effect of nanoparticles for medical use on pulmonary epithelial cells.
Laura BOUBLIL
Defense on 3/12/2012
Subject: Long-term effects of fine and ultrafine atmospheric particles: involvement in bronchial remodelling.