Molecular and Cellular Perturbations and (MCPX)

Theses defended since 2012

2024

• Tessa ARNAUD – Molecular and cellular responses to xenobiotics team
  Defended on 27/09/2024
  Subject: Study of the regulation of PTP1B by naphthoquinones: impact on EGFR and cellular consequences

• Chloé CHIVE – Molecular and cellular responses to xenobiotics team
  Defended on 25/09/2024
  Subject: Effects of exposure to fine particles on the severity of infection by the Influenza virus

2023

• Louise LE COADOU – Molecular and cellular responses to xenobiotics team
  Defense on 14/12/2023
  Subject: Histone lysine methyltransferase SETD2: Functional and structural characterisation of the recurrent oncogenic SETD2 mutation S1624C and of the methylation of a non-histone substrate, the tyrosine kinase ACK1.

2022

• Christina MICHAIL – Molecular and cellular responses to xenobiotics team
  Defended on 15/12/2022
  Subject: Structural and functional characterisation of oncogenic mutations in the histone methyltransferase SETD2 and the histone acetyltransferase MOZ.

• Rongxing LIU
  Defense on 19/07/2022
  Subject: Molecular effects of the anticancer drug cisplatin on the protein tyrosine phosphatase 1B (PTP1B) and structural impact of PTP1B cancer-associated mutations.

2021

• Daniel SANCHEZ GUZMAN
  Defense on 8/12/2021
  Subject: Development of a 3D bronchial epithelium model for nanotoxicology: analysis of the protein corona formation on silver nanoparticles in the secretome.

2020

• Wenchao ZHANG
  Defense on 15/12/2020
  Subject: Secondary leukemia associated with anti-cancer drugs and epigenetic alterations – Role of the histone acetyltransferase CREBBP.

2019

• Qing NIAN
  Defense on 16/07/2019
  Subject : Inhibition of protein tyrosine phosphatase PTPN2 by etoposide quinone and functional characterization of a pathological mutant.
• Jérémy BERTHELET
  Defense on 14/06/2019
  Subject: Effects of reactive benzene metabolites and an oncogenic mutation on SetD2, a histone methyltransferase.

2018

• Chloé PUISNEY
  Defense on 27/09/2018
  Subject : Fate and impacts of manufactured nanoparticles and from brake wear on the respiratory epithelial barrier.

2016

• Romain DUVAL
  Defense on 28/04/2016
  Subject: Benzene and leukaemia: study of the effect of reactive benzene metabolites on the histone acetyltransferase CBP.
• Cécile MATHIEU
  Defense on 30/09/2016
  Subject : Structure and regulation of brain glycogen phosphorylase.

2015

• Mathilde DELAVAL
  Defense on 30/11/2015
  Subject : Effects of cerium oxide nanoparticles on respiratory epithelium in vitro.

2014

• Mélanie LOVERA-LEROUX
  Defense on 31/03/2014
  Subject : Study of the mechanisms regulating apoptotic cell death by atmospheric particles and their metallic compounds.
• Isabelle GEORGE
  Defense on 23/09/2014
  Subject : Respiratory epithelium, target of inhaled nanoparticles: translocation and long-term effects.
• Ximing XU
  Defense on 25/09/2014
  Subject : Arylamines N-acetyltransferases: cofactor binding, catalytic mechanism and inhibition by dithiocarbamates.

2013

• Sandra VRANIC
  Defense on 18/02/2013
  Subject: Study of the toxicity of nanoparticles on respiratory cells: role of physicochemical properties and endocytosis.
• Angélique COCAIGN
  Defense on 25/09/2013
  Subject : Molecular basis of the detoxification properties of cosmopolitan fungi.

2012

• Xavier KUBIAK
  Defense on 20/09/2012
  Subject : Functional and structural study of atypical arylamine N-acetyltransferases in Legionella pneumophila and Bacillus cereus.
• Rina GUADAGNINI
  Subject: Effect of nanoparticles for medical use on pulmonary epithelial cells.
• Laura BOUBLIL
  Defense on 3/12/2012
  Subject: Long-term effects of fine and ultrafine atmospheric particles: involvement in bronchial remodelling.