Regulation of Glycemia by Central Nervous System – Publications

REGLYS

Articles

2024

Dahik, V. D., Kc, P., Materne, C., Reydellet, C., Lhomme, M., Cruciani-Guglielmacci, C., Denom, J., Bun, E., Ponnaiah, M., Deknuydt, F., Frisdal, E., Hardy, L. M., Durand, H., Guillas, I., Lesnik, P., Gudelj, I., Lauc, G., Guérin, M., Kontush, A., … Le Goff, W. (2024). ABCG1 orchestrates adipose tissue macrophage plasticity and insulin resistance in obesity by rewiring saturated fatty acid pools. Science Translational Medicine, 16(777), eadi6682.

Mehl, F., Sánchez-Archidona, A. R., Meitil, I., Gerl, M., Cruciani-Guglielmacci, C., Wigger, L., Le Stunff, H., Meneyrol, K., Lallement, J., Denom, J., Klose, C., Simons, K., Pagni, M., Magnan, C., Ibberson, M., & Thorens, B. (2024). A multiorgan map of metabolic, signaling, and inflammatory pathways that coordinately control fasting glycemia in mice. IScience, 111134. https://doi.org/10.1016/j.isci.2024.111134

Montaner, M., Denom, J., Simon, V., Jiang, W., Holt, M. K., Brierley, D. I., Rouch, C., Foppen, E., Kassis, N., Jarriault, D., Khan, D., Eygret, L., Mifsud, F., Hodson, D. J., Broichhagen, J., Van Oudenhove, L., Fioramonti, X., Gault, V., Cota, D., … Magnan, C. (2024). A neuronal circuit driven by GLP-1 in the olfactory bulb regulates insulin secretion. Nature Communications, 15(1), 6941. https://doi.org/10.1038/s41467-024-51076-4

Cruciani-Guglielmacci, C., Le Stunff, H., & Magnan, C. (2024). Brain lipid sensing and the neural control of energy balance. Biochimie, S0300-9084(24)00122-6. https://doi.org/10.1016/j.biochi.2024.05.020

Dard R, Tutunaru A, Bouassida M, Balde A, Parizot E, Kassis N, Fortemps J, Cierniewski C, Racine C, Di-Clemente N, Vialard F, Janel N. Spermatogonial depletion and spermatogenesis defect in Dp16/1Yey mouse model of Down syndrome. Reproduction, 2024, 167, e230233.

Metherel, A. H., Valenzuela, R., Klievik, B. J., Cisbani, G., Rotarescu, R. D., Gonzalez-Soto, M., Cruciani-Guglielmacci, C., Layé, S., Magnan, C., Mutch, D. M., & Bazinet, R. P. (2024). Dietary docosahexaenoic acid (DHA) downregulates liver DHA synthesis by inhibiting eicosapentaenoic acid elongation. Journal of Lipid Research, 65(6), 100548. https://doi.org/10.1016/j.jlr.2024.100548

Corporeau, C., Le Foll, C., Cruciani-Guglielmacci, C., Le Stunff, H., Mithieux, G., Magnan, C., & Delarue, J. (2024). Fish oil minimises feed intake and improves insulin sensitivity in Zucker fa/fa rats. The British Journal of Nutrition, 131(5), 749–761. https://doi.org/10.1017/S0007114523002404

Diao, S., Chen, C., Benani, A., Magnan, C., Van Steenwinckel, J., Gressens, P., Cruciani-Guglielmacci, C., Jacquens, A., & Bokobza, C. (2024). Preterm birth: A neuroinflammatory origin for metabolic diseases? Brain, Behavior, & Immunity – Health, 37, 100745. https://doi.org/10.1016/j.bbih.2024.100745

Dos Santos, R. M., Miyamoto, J. É., Siqueira, B. P., Araujo, T. R., Vettorazzi, J. F., Menta, P. L. R., Denom, J., Latorraca, M. Q., Cruciani-Guglielmacci, C., Carneiro, E. M., Torsoni, A., Torsoni, M., Badan, A. P., Magnan, C., Le Stunff, H., Ignácio-Souza, L., & Milanski, M. (2024). Interesterified palm oil promotes insulin resistance and altered insulin secretion and signaling in Swiss mice. Food Research International (Ottawa, Ont.), 177, 113850. https://doi.org/10.1016/j.foodres.2023.113850

Magnan, C. (2024). Editorial of the Special Section “Role of nutrients in nervous control of energy balance.” Biochimie, S0300908424001445. https://doi.org/10.1016/j.biochi.2024.06.008

Moreau, M., Dard, R., Madani, A., Kandiah, J., Kassis, N., Ziga, J., Castiglione, H., Day, S., Bourgeois, T., Matrot, B., Vialard, F., & Janel, N. (2024). Prenatal treatment with preimplantation factor improves early postnatal neurogenesis and cognitive impairments in a mouse model of Down syndrome. Cellular and Molecular Life Sciences: CMLS, 81(1), 215. https://doi.org/10.1007/s00018-024-05245-9

Tolu S, Hamzé R, Moreau M, Bertrand Romane, Janel N*, Movassat J*. Beta cell function and global glucose metabolism are impaired in Dp(16)1Yey mouse model of Down Syndrome. Diabetes, Obesity and Metabolism, 2025, sous presse.

Delabar JM, Gomes MAGB, Fructuoso M, Sarrazin N, George N, Fleary-Roberts N, Sun H, Bui LC, Rodrigues-Lima F, Janel N, Dairou J, Maria EJ, Dodd RH, Cariou K, Potier MC. EGCG-like non-competitive inhibitor of DYRK1A rescues cognitive defect in a Down syndrome mouse model. European Journal of Medicinal Chemistry, 2024, 265, 116098.

Moro, C., & Magnan, C. (2024). Revisited guidelines for metabolic tolerance tests in mice. Lab Animal. https://doi.org/10.1038/s41684-024-01473-5

2023

Lallement, J., Raho, I., Merlen, G., Rainteau, D., Croyal, M., Schiffano, M., Kassis, N., Doignon, I., Soty, M., Lachkar, F., Krempf, M., Van Hul, M., Cani, P. D., Foufelle, F., Amouyal, C., Le Stunff, H., Magnan, C., Tordjmann, T., & Cruciani-Guglielmacci, C. (2023). Hepatic deletion of serine palmitoyl transferase 2 impairs ceramide/sphingomyelin balance, bile acids homeostasis and leads to liver damage in mice. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids, 1868(8), 159333. https://doi.org/10.1016/j.bbalip.2023.159333

Postic G, Solarz J, Loubière C, Kandiah J, Sawmynaden J, Adam F, Vilaire M, Léger T, Camadro M, Balduino Victorino D, Potier MC, Bun E, Moroy G, Kauskot A, Christophe O, Janel N. Over-expression of Dyrk1A affects bleeding by modulating plasma fibronectin and fibrinogen level in mice. J Cell Mol Med, 2023, 27, 2228-2238.

Fructuoso M, Fernández-Blanco A, Gallego-Román A, Sierra C, Martínez de Lagrán M, Lorenzon N, de Toma I, Langohr K, Martín-García E, Maldonado ER, Dairou J, Janel N, Dierssen M. Exploring the Link between Hedonic Overeating and Prefrontal Cortex Dysfunction in the Ts65Dn Trisomic Mouse Model. Cell Mol Life Sci, 2023, 80, 370.

Diepenbroek, C., Rijnsburger, M., van Irsen, A. A. S., Eggels, L., Kisner, A., Foppen, E., Unmehopa, U. A., Berland, C., Dólleman, S., Hardonk, M., Cruciani-Guglielmacci, C., Faust, R. P., Wenning, R., Maya-Monteiro, C. M., Kalsbeek, A., Aponte, Y., Luquet, S., Serlie, M. J. M., & la Fleur, S. E. (2024). Dopamine in the nucleus accumbens shell controls systemic glucose metabolism via the lateral hypothalamus and hepatic vagal innervation in rodents. Metabolism: Clinical and Experimental, 150, 155696. https://doi.org/10.1016/j.metabol.2023.155696

Gonzalez, P., Dos Santos, A., Darnaud, M., Moniaux, N., Rapoud, D., Lacoste, C., Nguyen, T.-S., Moullé, V. S., Deshayes, A., Amouyal, G., Amouyal, P., Bréchot, C., Cruciani-Guglielmacci, C., Andréelli, F., Magnan, C., & Faivre, J. (2023). Antimicrobial protein REG3A regulates glucose homeostasis and insulin resistance in obese diabetic mice. Communications Biology, 6(1), 269. https://doi.org/10.1038/s42003-023-04616-5

Yu, C.-Y., Chammas, M., Gurden, H., Lin, H.-H., & Pain, F. (2023). Design and validation of a convolutional neural network for fast, model-free blood flow imaging with multiple exposure speckle imaging. Biomedical Optics Express, 14(9), 4439–4454. https://doi.org/10.1364/BOE.492739

Tartarin P, Keller M, Guibert E, Trives E, Bourdon G, Chamero P, Negre D, Cornilleau F, Guillory V, JeanPierre E, Costa C, Migrenne S, Dupont J, Froment P. Knockdown of regulatory associated protein of TOR (raptor) in hypothalamus stimulated folliculogenesis and induced ovarian cysts. Reprod Fertil Dev. 2023 Jan 3 (Q2)

2022

Ladraa S, Zerbib L, Bayard C, Fraissenon A, Venot Q, Morin G, Garneau AP, Isnard P, Chapelle C, Hoguin C, Fraitag S, Duong JP, Guibaud L, Besançon A, Kaltenbach S, Villarese P, Asnafi V, Broissand C, Goudin N, Dussiot M, Nemazanyy I, Viel T, Autret G, Cruciani-Guglielmacci C, Denom J, Bruneau J, Tavitian B, Legendre C, Dairou J, Lacorte JM, Levy P, Pende M, Polak M, Canaud G. PIK3CA gain-of-function mutation in adipose tissue induces metabolic reprogramming with Warburg-like effect and severe endocrine disruption. Sci Adv. 2022 Dec 9;8(49):eade7823. (Q1)

Le Lay A, Philippe E, Roth F, Rodriguez Sanchez-Archidona A, Mehl F, Denom J, Prasad R, Asplund O, Hansson O, OIbberson M, Andreelli F, Santoro L, Amouyal P, Amouyal G, Christian Brechot C, Jamot L, Cruciani- Guglielmacci C, Magnan C. Regenerating islet-derived protein 3α: a promising therapy for diabetes. Preliminary data in rodents and in humans. Heliyon. 2022 Jul 16;8(7):e09944. (Q1)

Joly-Amado A, Soty M, Philippe E, Lacombe A, Castel J, Pillot B, Vily-Petit J, Zitoun C, Mithieux G, Magnan C. Portal Glucose Infusion, Afferent Nerve Fibers, and Glucose and Insulin Tolerance of Insulin-Resistant Rats. J Nutr. 2022 Aug 9;152(8):1862-1871. (Q1)

Wiedemann SJ, Trimigliozzi K, Dror E, Meier DT, Molina-Tijeras JA, Rachid L, Le Foll C, Magnan C, Schulze F, Stawiski M, Häuselmann SP, Méreau H, Böni-Schnetzler M, Donath MY. The cephalic phase of insulin release is modulated by IL-1β. Cell Metabolism, 2022 Jul 5;34(7):991-1003.e6. (Q1)

Mifsud F, Saint-Martin C, Dubois-Laforgue D, Bouvet D, Timsit J, Bellanné-Chantelot C, on behalf of the Monogenic Diabetes Study Group of the Société Francophone du Diabète. Monogenic diabetes in adults: A multi-ancestry study reveals strong disparities in diagnosis rates and clinical presentation. Diabetes Research and Clinical Practice June 2022, Volume 188, 109908. (Q1)

Cruciani-Guglielmacci C, Meneyrol K, Denom J, Kassis N, Rachdi L, Makaci F, Migrenne-Li S, Daubigney F, Georgiadou E, Denis RG, Rodriguez Sanchez- Archidona A, Paul JL, Thorens B, Rutter GA, Magnan C, le Stunff H, Janel N. Homocysteine metabolism pathway is involved in the control of glucose homeostasis: a cystathionine beta synthase deficiency study in Mouse. Cells. 2022 May 25;11(11):1737. (Q1)

Moreau M, Carmona-Iragui M, Altuna M, Dalzon L, Barroeta I, Vilaire M, Durand S, Fortea J, Rebillat AS, Janel N. DYRK1A and activity-dependent neuroprotective protein comparative diagnosis interest in cerebrospinal fluid and plasma in the context of Alzheimer-related cognitive impairment in Down syndrome patients. Biomedicines, 2022, 10, 1380.

Fougerat A, Schoiswohl G, Polizzi A, Régnier M, Wagner C, Smati S, Fougeray T, Lippi Y, Lasserre F, Raho I, Melin V, Tramunt B, Métivier R, Sommer C, Benhamed F, Alkhoury C, Greulich F, Jouffe C, Emile A, Schupp M, Gourdy P, Dubot P, Levade T, Meynard D, Ellero-Simatos S, Gamet-Payrastre L, Panasyuk G, Uhlenhaut H, Amri EZ, Cruciani-Guglielmacci C, Postic C, Wahli W, Loiseau N, Montagner A, Langin D, Lass A, Guillou H. ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity. Cell Rep. 2022 Jun 7;39(10):110910. (Q1)

Garrel G, Rouch C, L’Hôte D, Tazi S, Kassis N, Giton F, Dairou J, Dournaud P, Gressens P, Magnan C, Cruciani- Guglielmacci C, Cohen-Tannoudji J. Disruption of Pituitary Gonadotrope Activity in Male Rats After Short- or Long-Term High-Fat Diets Is Not Associated With Pituitary Inflammation. Front Endocrinol (Lausanne). 2022 Apr 13;13:877999. (Q1)

Ghoula M, Janel N, Camproux AC, Moroy G. Exploring the structural rearrangements of the human Insulin Degrading Enzyme through Molecular Dynamics simulations. Int. J. Mol. Sci., 2022, 23, 1746.

Georgiadou E, Muralidharan C, Martinez M, Chabosseau P, Akalestou E, Tomas A, Yong Su Wern F, Stylianides T, Wretlind A, Legido-Quigley C, Jones B, Lopez Noriega L, Xu Y, Gu G, Alsabeeh N, Cruciani-GuglielmacciC, Magnan C, Ibberson M, Leclerc I, Ali Y, Soleimanpour SA, Linnemann AK, Rodriguez TA, Rutter GA. Mitofusins Mfn1 and Mfn2 are Required to Preserve Glucose- But Not Incretin-Stimulated Beta Cell Connectivity and Insulin Secretion. Diabetes. 2022 Apr 26;db210800. (Q1)

Deckmyn B, Domenger D, Blondel C, Ducastel S, Nicolas E, Dorchies E, Caron E, Charton J, Vallez E, Deprez B, Annicotte JS, Lestavel S, Tailleux A, Magnan C, Staels B, Bantubungi K. Farnesoid X Receptor Activation in Brain Alters Brown Adipose Tissue Function via the Sympathetic System. Front Mol Neurosci. 2022 Jan 4;14:808603. (Q1)

Souchet B, Audrain M, Gu Y, Lindberg MF, Orefice NS, Rey E, Cartier N, Janel N, Meijer L, Braudeau J. Cerebral phospho-tau acts synergistically with soluble Aβ42 leading to Mild Cognitive Impairment in AAV-AD rats. Journal of Prevention of Alzheimer’s Disease, 2022, 9, 480-490.

Cieuta-Walti C, Cuenca Royo A, Langohr, K, Rakic, C, López Vílchez, A, Lirio, J, González-Lamuño Leguina, D, Bermejo González, T, García García, J, Rimblas Roure, M, Aldea Perona, A, Gomis, M, Videla Cés, S, Lacaille F, Ravel A, Mircher C, Walti, H, Janel N, Dairou J, Lévy M, Durand S, Dierssen M, Sacco S, De la Torre R. Safety and Preliminary Efficacy on Cognitive Performance and Adaptive Functionality of Epigallocatechin Gallate (EGCG) in Children with Down Syndrome. A Randomized Phase Ib Clinical Trial (PERSEUS study). Genetics in Medicine, 2022, 24, 2004-2013.

2021

Dard R, Moreau M, Parizot E, Ghieh F, Brehier L, Kassis N, Serazin V, Lamaziere A, Racine C, di Clemente N, Vialard F, Janel N. DYRK1A Overexpression in Mice Downregulates the Gonadotropic Axis and Disturbs Early Stages of Spermatogenesis. Genes (Basel). 2021 Nov 16;12(11):1800. (Q2)

Sánchez-Archidona AR, Cruciani-Guglielmacci C, Roujeau C, Wigger L, Lallement J, Denom J, Barovic M, Kassis N, Mehl F, Weitz J, Distler M, Klose C, Simons K, Ibberson M, Solimena M, Magnan C, Thorens B. Plasma triacylglycerols are biomarkers of β-cell function in mice and humans. Mol Metab. 2021 Dec;54:101355. (Q1)

Meneyrol K, Estévez-Salguero Á, González-García I, Guitton J, Taouis M, Benomar Y, Magnan C, López M, Le Stunff H. Ovarian insufficiency impairs glucose-stimulated insulin secretion through activation of hypothalamic de novo ceramide synthesis. Metabolism. 2021 Oct;123:154846. (Q1)

Denis F, Septans AL, Periers L, Maillard JM, Legoff F, Gurden H, Moriniere S. Olfactory Training and Visual Stimulation Assisted by a Web Application for Patients With Persistent Olfactory Dysfunction After SARS-CoV- 2 Infection: Observational Study. J Med Internet Res. 2021 May 27;23(5):e29583. doi: 10.2196/29583. Erratum in: J Med Internet Res. 2021 Jul 16;23(7):e32120 (Q1)

Mousavy Gharavy SN, Owen BM, Millership SJ, Chabosseau P, Pizza G, Martinez- Sanchez A, Tasoez E, Georgiadou E, Hu M, Fine NHF, Jacobson DA, Dickerson MT, Idevall-Hagren O, Montoya A, Kramer H, Mehta Z, Withers DJ, Ninov N, Gadue PJ, Cardenas-Diaz FL, Cruciani-Guglielmacci C, Magnan C, Ibberson M, Leclerc I, Voz M, Rutter GA. Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis. Diabetologia. 2021 Apr;64(4):850-864. (Q1)

Postic G, Janel N, Moroy G. Representations of protein structure for exploring the conformational space: a speed–accuracy trade-off. Computational and Structural Biotechnology Journal, 2021, 19, 2618-2625.

2020

Ghoula M, Le Marec A, Magnan C, Le Stunff H, Taboureau O. Identification of the Interactions Interference Between the PH and START Domain of CERT by Limonoid and HPA Inhibitors. Front Mol Biosci. 2020 Nov 27;7:603983. (Q1)

Soleimanzad H, Montaner M, Ternier G, Lemitre M, Silvestre JS, Kassis N, Giacobini P, Magnan C, Pain F, Gurden H. Obesity in Midlife Hampers Resting and Sensory-Evoked Cerebral Blood Flow in Mice. Obesity (Silver Spring). 2020 Nov. (Q1)

Brial F, Alzaid F, Sonomura K, Kamatani Y, Meneyrol K, Le Lay A, Péan N, Hedjazi L, Sato TA, Venteclef N, Magnan C, Lathrop M, Dumas ME, Matsuda F, Zalloua P, Gauguier D. The Natural Metabolite 4-Cresol Improves Glucose Homeostasis and Enhances β-Cell Function. Cell Rep. 2020 Feb 18;30(7):2306-2320.e5. (Q1)

Péan N, Le Lay A, Brial F, Wasserscheid J, Rouch C, Vincent M, Myridakis A, Hedjazi L, Dumas ME, Grundberg E, Lathrop M, Magnan C, Dewar K, Gauguier D. Dominant gut Prevotella copri in gastrectomised non-obese diabetic Goto-Kakizaki rats improves glucose homeostasis through enhanced FXR signalling. Diabetologia. 2020 Jun;63(6):1223-1235. (Q1)

Gu Y, Moroy G, Paul JL, Rebillat AS, Dierssen M, de la Torre R, Cieuta-Walti C, Dairou J, Janel N. Molecular rescue of Dyrk1A overexpression alterations in mice with Fontup® dietary supplement: role of green tea catechins. Int. J. Mol. Sci. 2020, 21, E1404.

Portovedo M, Reginato A, Miyamoto JÉ, Simino LA, Hakim MP, Campana M, Leal RF, Ignácio-Souza LM, Torsoni MA, Magnan C, Le Stunff H, Torsoni AS, Milanski M. Lipid excess affects chaperone-mediated autophagy in hypothalamus. Biochimie. 2020 Sep;176:110-116. (Q1)

Joseph A, Moriceau S, Sica V, Anagnostopoulos G, Pol J, Martins I, Lafarge A, Maiuri MC, Leboyer M, Loftus J, Bellivier F, Belzeaux R, Berna F, Etain B, Capdevielle D, Courtet P, Dubertret C, Dubreucq J, Thierry A, Fond G, Gard S, Llorca PM, Mallet J, Misdrahi D, Olié E, Passerieux C, Polosan M, Roux P, Samalin L, Schürhoff F, Schwan R; FACE-SZ and FACE-BD (FondaMental Academic Centers of Expertise, for Schizophrenia and for Bipolar Disorder) Groups, Magnan C, Oury F, Bravo-San Pedro JM, Kroemer G. Metabolic and psychiatric effects of acyl coenzyme A binding protein (ACBP)/diazepam binding inhibitor (DBI). Cell Death Dis. 2020 Jul 6;11(7):502. (Q1)

Gausserès B, Liu J, Foppen E, Tourrel-Cuzin C, Rodriguez Sanchez-Archidona A, Delangre E, Cruciani-Guglielmacci C, Pons S, Maskos U, Thorens B, Magnan C, Movassat J, Maouche K. The Constitutive Lack of α7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse. Biomolecules. 2020 Jul 16;10(7):1057. (Q2)

Amouyal C, Castel J, Guay C, Lacombe A, Denom J, Migrenne-Li S, Rouault C, Marquet F, Georgiadou E, Stylianides T, Luquet S, Le Stunff H, Scharfmann R, Clément K, Rutter GA, Taboureau O, Magnan C1, Regazzi R1, Andreelli F1. 1These authors contributed equally to this work. A surrogate of Roux-en-Y gastric bypass (the enterogastro anastomosis surgery) regulates multiple beta-cell pathways during resolution of diabetes in ob/ob mice. EBioMedicine. 2020 Aug;58:102895. (Q1)

Fructuoso M, Gu YC, Kassis N, de Lagran MM, Dierssen M, Janel N. Ethanol- Induced Changes in Brain of Transgenic Mice Overexpressing DYRK1A. Mol Neurobiol. 2020 Jul;57(7):3195-3205. doi: 10.1007/s12035-020-01967-6. Epub 2020 Jun 5 (Q1)

Postic G, Janel N, Tufféry P, Moroy G. An information gain-based approach for evaluating protein structure models. Computational and Structural Biotechnology Journal, 2020, 18, 2228-2236.

2019

Movassat J, Delangre E, Liu Junjun, Gu Yuchen, Janel N. Circulating Alzheimer’s-related biomarkers in type 2 diabetes. Insight from the Goto-Kakizaki rat. Front Neurol, 2019, 10, 649.

Oshima M, Pechberty S, Bellini L, Göpel SO, Campana M, Rouch C, Dairou J, Cosentino C, Fantuzzi F, Toivonen S, Marchetti P, Magnan C, Cnop M, Le Stunff H, Scharfmann R. Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity. Diabetologia. 2020 Feb;63(2):395-409. (Q1)

Fumeron F, Nicolas A, Bastard JP, Fellahi S, Wigger L, Ibberson M, Cruciani-Guglielmacci C, Le Stunff H, Velho G, Magnan C, Marre M, Balkau B, Roussel R. Dairy consumption is associated with lower plasma dihydroceramides in women from the D.E.S.I.R. cohort. Diabetes Metab. 2020 Apr;46(2):144-149. (Q1)

Abarkan M, Gaitan J, Lebreton F, Perrier R, Jaffredo M, Mulle C, Magnan C, Raoux M, Lang J. The glutamate receptor GluK2 contributes to the regulation of glucose homeostasis and its deterioration during aging. Mol Metab. 2019 Dec;30:152-160 (Q1)

Mortreux M, Foppen E, Denis RG, Montaner M, Kassis N, Denom J, Vincent M, Fumeron F, Kujawski-Lafourcade M, Andréelli F, Balkau B, Marre M, Roussel R, Magnan C, Gurden H, Migrenne-Li S. New roles for prokineticin 2 in feeding behavior, insulin resistance and type 2 diabetes: Studies in mice and humans. Mol Metab. 2019 Nov;29:182-196 (Q1)

Bravo-San Pedro JM, Sica V, Martins I, Pol J, Loos F, Maiuri MC, Durand S, Bossut N, Aprahamian F, Anagnostopoulos G, Niso-Santano M, Aranda F, Ramírez-Pardo I, Lallement J, Denom J, Boedec E, Gorwood P, Ramoz N, Clément K, Pelloux V, Rohia A, Pattou F, Raverdy V, Caiazzo R, Denis RGP, Boya P, Galluzzi L, Madeo F, Migrenne-Li S, Cruciani-Guglielmacci C, Tavernarakis N, López-Otín C, Magnan C, Kroemer G. Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity. Cell Metab. 2019 Oct 1;30(4):754-767.e9 (Q1)

Le Stunff H, Véret J, Kassis N, Denom J, Meneyrol K, Paul JL, Cruciani-Guglielmacci C, Magnan C, Janel N. Deciphering the Link Between Hyperhomocysteinemia and Ceramide Metabolism in Alzheimer-Type Neurodegeneration. Front Neurol. 2019 Jul 31;10:807 (Q1)

Souchet B, Duchon A, Gu Y, Dairou J, Chevalier C, Daubigney F, Nalesso V, Créau N, Yu E, Janel N, Herault Y, Delabar JM. Prenatal treatment with EGCG enriched green tea extract rescues GAD67 related developmental and cognitive defects in Down syndrome mouse models. Scientific Reports, 2019, 9, 3914.

Souchet B, Audrain M, Billard JM, Dairou J, Fol R, Orefice NS, Tada S, Gu Y, Dufayet-Chaffaud G, Limanton E, Carreaux F, Bazureau JP, Alves S, Meijer L, Janel N, Braudeau J, Cartier N. Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice. Acta Neuropathologica Communications, 2019, 7, 46

London J, Ndiaye FK, Bui LC, Souchet B, Daubigney F, Magnan C, Luquet S, Dairou J, Janel N, Rouch C. Alterations in the Serotonin and Dopamine Pathways by Cystathionine Beta Synthase Overexpression in Murine Brain. Mol Neurobiol. 2019 Jun;56(6):3958-3971 (Q1)

Dalle H, Garcia M, Antoine B, Boehm V, Do TTH, Buyse M, Ledent T, Lamazière A, Magnan C, Postic C, Denis RG, Luquet S, Fève B, Moldes M. Adipocyte Glucocorticoid Receptor Deficiency Promotes Adipose Tissue Expandability and Improves the Metabolic Profile Under Corticosterone Exposure. Diabetes. 2019 Feb;68(2):305-317 (Q1)

Desmoulins L, Chrétien C, Paccoud R, Collins S, Cruciani-Guglielmacci C, Galinier A, Liénard F, Quinault A, Grall S, Allard C, Fenech C, Carneiro L, Mouillot T, Fournel A, Knauf C, Magnan C, Fioramonti X, Pénicaud L, Leloup C. Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing. Mol Metab. 2019 Feb;20:166-177 (Q1)

Soleimanzad H, Smekens F, Peyronnet J, Juchaux M, Lefebvre O, Bouville D, Magnan C, Gurden H, Pain F. Multiple speckle exposure imaging for the study of blood flow changes induced by functional activation of barrel cortex and olfactory bulb in mice. Neurophotonics. 2019 Jan;6(1):015008 (Q1)

Gnaedinger A, Gurden H, Gourévitch B, Martin C. Multisensory learning between odor and sound enhances beta oscillations. Sci Rep. 2019 Aug 2;9(1):11236 (Q1)

Latour A, Gu Y, Kassis N, Daubigney F, Colin C, Gausserès B, Middendorp S, Paul JL, Hindié V, Rain JC, Delabar JM, Yu E, Arbones M, Mallat M, Janel N. LPS-Induced Inflammation Abolishes the Effect of DYRK1A on IkB Stability in the Brain of Mice. Mol Neurobiol. 2019 Feb;56(2):963-975 (Q1)

2018

Montana L, Lamon M, Barrat C, Hansel B, Magnan C, Arapis K. Establishing a Reproducible Murine Animal Model of Single Anastomosis Duodenoileal Bypass with Sleeve Gastrectomy (SADl-S). Obes Surg. 2018 Jul;28(7):2122-2125. (Q1)

Bellini L, Campana M, Rouch C, Chacinska M, Bugliani M, Meneyrol K, Hainault I, Lenoir V, Denom J, Véret J, Kassis N, Thorens B, Ibberson M, Marchetti P, Blachnio-Zabielska A, Cruciani-Guglielmacci C, Prip-Buus C, Magnan C, Le Stunff H. Protective role of the ELOVL2/docosahexaenoic acid axis in glucolipotoxicity-induced apoptosis in rodent beta cells and human islets. Diabetologia. 2018 Aug;61(8):1780-1793 (Q1)

Campana M, Bellini L, Rouch C, Rachdi L, Coant N, Butin N, Bandet CL, Philippe E, Meneyrol K, Kassis N, Dairou J, Hajduch E, Colsch B, Magnan C, Le Stunff H. Inhibition of central de novo ceramide synthesis restores insulin signaling in hypothalamus and enhances β-cell function of obese Zucker rats. Mol Metab. 2018 Feb;8:23-36 (Q1)

Fructuoso M, Rachdi L, Philippe E, Denis RG, Magnan C, Le Stunff H, Janel N, Dierssen M. Increased levels of inflammatory plasma markers and obesity risk in a mouse model of Down syndrome. Free Radic Biol Med. 2018 Jan;114:122-130 (Q1)

González-García I, Contreras C, Estévez-Salguero Á, Ruíz-Pino F, Colsh B, Pensado I, Liñares-Pose L, Rial-Pensado E, Martínez de Morentin PB, Fernø J, Diéguez C, Nogueiras R, Le Stunff H, Magnan C, Tena-Sempere M, López M. Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress. Cell Rep. 2018 Oct 9;25(2):413-423.e5 (Q1)

Baloula V, Fructuoso M, Kassis N, Gueddouri D, Paul JL, Janel N. Homocysteine-lowering gene therapy rescues signaling pathways in brain of mice with intermediate hyperhomocysteinemia. Redox Biol. 2018 Oct;19:200-209 (Q1)

Charpentier J, Waget A, Klopp P, Magnan C, Cruciani-Guglielmacci C, Lee SJ, Burcelin R, Grasset E. Lixisenatide requires a functional gut-vagus nerve-brain axis to trigger insulin secretion in controls and type 2 diabetic mice. Am J Physiol Gastrointest Liver Physiol. 2018 Nov 1;315(5):G671-G684 (Q1)

Bandet CL, Mahfouz R, Véret J, Sotiropoulos A, Poirier M, Giussani P, Campana M, Philippe E, Blachnio-Zabielska A, Ballaire R, Le Liepvre X, Bourron O, Berkeš D, Górski J, Ferré P, Le Stunff H, Foufelle F, Hajduch E. Ceramide Transporter CERT Is Involved in Muscle Insulin Signaling Defects Under Lipotoxic Conditions. Diabetes. 2018 Jul;67(7):1258-1271 (Q1)

Hoyles L, Jiménez-Pranteda ML, Chilloux J, Brial F, Myridakis A, Aranias T, Magnan C, Gibson GR, Sanderson JD, Nicholson JK, Gauguier D, McCartney AL, Dumas ME. Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota. Microbiome. 2018 Apr 20;6(1):73 (Q1)

Laperrousaz E, Denis RG, Kassis N, Contreras C, López M, Luquet S, Cruciani-Guglielmacci C, Magnan C. Lipoprotein Lipase Expression in Hypothalamus Is Involved in the Central Regulation of Thermogenesis and the Response to Cold Exposure. Front Endocrinol (Lausanne). 2018 Mar 14;9:103 (Q1)

London J, Rouch C, Bui LC, Assayag E, Souchet B, Daubigney F, Medjaoui H, Luquet S, Magnan C, Delabar JM, Dairou J, Janel N. Overexpression of the DYRK1A Gene (Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A) Induces Alterations of the Serotoninergic and Dopaminergic Processing in Murine Brain Tissues. Mol Neurobiol. 2018 May;55(5):3822-3831 (Q1)

2017

Gao Y, Layritz C, Legutko B, Eichmann TO, Laperrousaz E, Moullé VS, Cruciani-Guglielmacci C, Magnan C, Luquet S, Woods SC, Eckel RH, Yi CX, Garcia-Caceres C, Tschöp MH. Disruption of Lipid Uptake in Astroglia Exacerbates Diet-Induced Obesity. Diabetes. 2017 Oct;66(10):2555-2563 (Q1)

Rijnsburger M, Eggels L, Castel J, Cruciani-Guglielmacci C, Ackermans MT, Luquet S, la Fleur SE. A novel, double intra-carotid cannulation technique to study the effect of central nutrient sensing on glucose metabolism in the rat. J Neurosci Methods. 2017 Oct 1;290:79-84 (Q2)

Lerat H, Imache MR, Polyte J, Gaudin A, Mercey M, Donati F, Baudesson C, Higgs MR, Picard A, Magnan C, Foufelle F, Pawlotsky JM. Hepatitis C virus induces a prediabetic state by directly impairing hepatic glucose metabolism in mice. J Biol Chem. 2017 Aug 4;292(31):12860-12873 (Q1)

Laperrousaz E, Moullé VS, Denis RG, Kassis N, Berland C, Colsch B, Fioramonti X, Philippe E, Lacombe A, Vanacker C, Butin N, Bruce KD, Wang H, Wang Y, Gao Y, Garcia-Caceres C, Prévot V, Tschöp MH, Eckel RH, Le Stunff H, Luquet S, Magnan C, Cruciani-Guglielmacci C. Lipoprotein lipase in hypothalamus is a key regulator of body weight gain and glucose homeostasis in mice. Diabetologia. 2017 Jul;60(7):1314-1324 (Q1)

Cruciani-Guglielmacci C, Bellini L, Denom J, Oshima M, Fernandez N, Normandie-Levi P, Berney XP, Kassis N, Rouch C, Dairou J, Gorman T, Smith DM, Marley A, Liechti R, Kuznetsov D, Wigger L, Burdet F, Lefèvre AL, Wehrle I, Uphues I, Hildebrandt T, Rust W, Bernard C, Ktorza A, Rutter GA, Scharfmann R, Xenarios I, Le Stunff H, Thorens B, Magnan C, Ibberson M. Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion. Mol Metab. 2017 Jan 26;6(4):340-351 (Q1)

Haddadi-Guemghar H, Tlili A, Dairou J, Paul Jean-Louis, Madania K, Janel N. Effect of prune extract on hyperhomocysteinemia in mice. Food Chem Toxicol, 2017,103, 183-187.

Janel N, Alexopoulos P, Badel A, Lamari F, Camproux AC, Lagarde J, Simon S, Feraudet-Tarisse C, Lamourette P, Arbones M, Paul JL, Dubois B, potier MC, Sarazin M, Delabar JM. Combined assessment of DYRK1A, BDNF, and homocysteine as predictive markers of Alzheimer’s disease. Transl Psychiatry. 2017, 7, e1154.

da Silva Xavier G, Mondragon A, Mourougavelou V, Cruciani-Guglielmacci C, Denom J, Herrera PL, Magnan C, Rutter GA. Pancreatic alpha cell-selective deletion of Tcf7l2 impairs glucagon secretion and counter-regulatory responses to hypoglycaemia in mice. Diabetologia. 2017 Jun;60(6):1043-1050 (Q1)

Tammaro P, Hansel B, Police A, Kousouri M, Magnan C, Marmuse JP, Arapis K. Laparoscopic Adjustable Gastric Banding: Predictive Factors for Weight Loss and Band Removal After More than 10 Years’ Follow-Up in a Single University Unit. World J Surg. 2017 Aug;41(8):2078-2086 (Q1)

Wigger L, Cruciani-Guglielmacci C, Nicolas A, Denom J, Fernandez N, Fumeron F, Marques-Vidal P, Ktorza A, Kramer W, Schulte A, Le Stunff H, Liechti R, Xenarios I, Vollenweider P, Waeber G, Uphues I, Roussel R, Magnan C, Ibberson M, Thorens B. Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans. Cell Rep. 2017 Feb 28;18(9):2269-2279 (Q1)

Arapis K, Tammaro P, Dorian S, Donatelli G, Pelletier AL, Dumont JL, Becheur H, Magnan C, Marmuse JP. Technical Aspects of Laparoscopic Janeway Gastrostomy: Is an Alternative Method Available to Access the Excluded Structures in Patients with Roux-en-Y Anatomy if Laparoscopy-Assisted Transgastric Endoscopic Retrograde Choledochopancreatoscopy is not Possible ? Obes Surg. 2017 Mar;27(3):630-640 (Q1)

Chelminski Y, Magnan C, Luquet S, Everard A, Meunier N, Gurden H, Martin C. Odor-induced neuronal rhythms in the olfactory bulb are profoundly modified in ob/ob obese mice. Front Physiol. 2017 Jan 19;8:2 (Q1)

Reviews

2024

Moreau M, Madani A, Dard R, Bourgeois T, d’Ortho MP, Delclaux C, Janel N, Matrot B. Utilisation des modèles murins pour l’étude du syndrome d’apnées obstructives du sommeil dans le syndrome de Down. Rev mal respir, 2024, 41, 279-282.

2023

Hamzé R, Delangre E, Tolu S, Moreau M, Janel N, Bailbé D, Movassat J. Type 2 Diabetes Mellitus and Alzheimer’s Disease: Shared Molecular Mechanisms and Potential Common Therapeutic Targets. Int. J. Mol. Sci., 2022, Int J Mol Sci, 23, 15287.

2022

Noll C, Kandiah J, Moroy G, Gu Y, Dairou J, Janel N. Catechins as dietary supplements in prevention of comorbidities linked with Down syndrome. Nutrients, 2022, 14, 2039.

Magnan C, Valet P. Editorial for special issue on « Endocrinology of adipokines ». Mol Cell Endocrinol. 2022 Jan 1;539:111498 (Q2)

2021

Faour M, Magnan C, Gurden H, Martin C. Olfaction in the context of obesity and diabetes: Insights from animal models to humans. Neuropharmacology. 2021 Dec 15;206:108923 (Q1)

Moro C, Magnan C. GTTs and ITTs: aim for shorter fasting times. Nat Metab. 2021 Sep;3(9):1133. Comment (Q1)

Magnan C, Le Stunff H. Role of hypothalamic de novo ceramides synthesis in obesity and associated metabolic disorders. Mol Metab. 2021 Nov;53:101298 (Q1)

Moreau M, Benhaddou S, Dard R, Tolu S, Hamzé R, Vialard F, Movassat J, Janel N. Metabolic diseases and Down syndrome: How are they linked together? Biomedicines, 2021, 9, 221.

Magnan C, Migrenne-Li S. Pleiotropic effects of prokineticin 2 in the control of energy metabolism. Biochimie. 2021 Jul;186:73-81. (Q1)

Montégut L, Lopez-Otin C, Magnan C, Kroemer G. Old Paradoxes and New Opportunities for Appetite Control in Obesity. Trends Endocrinol Metab. 2021 May;32(5):264-294 (Q1)

2020

Dard R, Janel N, Vialard F. COVID-19 and Down’s syndrome: are we heading for a disaster? Eur J of Hum Genet. 2020, 28, 1477-1478.

2019

Thorens B, Rodriguez A, Cruciani-Guglielmacci C, Wigger L, Ibberson M, Magnan C. Use of preclinical models to identify markers of type 2 diabetes susceptibility and novel regulators of insulin secretion – A step towards precision medicine. Mol Metab. 2019 Sep;27S:S147-S154 (Q1)

Parizot E, Dard R, Janel N, Vialard F. Down syndrome and infertility: what support should we provide? Journal of Assisted Reproduction and Genetics, 2019, 36, 1063-1067.

Marchetti P, Schulte AM, Marselli L, Schoniger E, Bugliani M, Kramer W, Overbergh L, Ullrich S, Gloyn AL, Ibberson M, Rutter G, Froguel P, Groop L, McCarthy MI, Dotta F, Scharfmann R, Magnan C, Eizirik DL, Mathieu C, Cnop M, Thorens B, Solimena M. Fostering improved human islet research: a European perspective. Diabetologia. 2019 Aug;62(8):1514-1516 (Q1)

Cruciani-Guglielmacci C, Fioramonti X. Editorial: Brain Nutrient Sensing in the Control of Energy Balance: New Insights and Perspectives. Front Physiol. 2019 Feb 5;10:51 (Q1)

2018

Le Marec A, Sungeelee S, Zeghouani A, Gonzalez L, Le Stunff H. [Role of ceramide metabolism in adipose browning: impact on energy homeostasis in obesity]. Med Sci (Paris). 2018 Feb;34(2):132-135 (Q1)

2017

Pénicaud L, Magnan C. Physiology and biochemistry of type 2 diabetes: A tribute to Dr Alain Ktorza. Biochimie. 2017 Dec;143:1-2 (Q1) Cruciani-Guglielmacci C, Magnan C. Brain lipoprotein lipase as a regulator of energy balance. Biochimie. 2017 Dec;143:51-55 (Q1)

Cruciani-Guglielmacci C, López M, Campana M, le Stunff H. Brain Ceramide Metabolism in the Control of Energy Balance. Front Physiol. 2017 Oct 12;8:787 Review (Q1)

REGLYS